Different applications of temperature responsive nanogels as a new drug delivery system mini review

Abstract

Temperature-sensitive drug delivery systems (TSDDS) are one of the systems that have received more attention in medical science these days due to their advantages. As these systems are sensitive to temperature, drug delivery to the target becomes more specific. Temperature-sensitive nanogels have many applications, including microbial infections, cancer therapy, transdermal use, and tissue repair. These systems are characterized by minimal toxicity, improved therapeutic efficacy, and reduced exposure to normal cells. This mini-review is prepared with different types of temperature-sensitive nanogel formation, release mechanisms, and their different applications. Various systems reported under these categories for targeted and controlled delivery of different classes of drugs, such as anti-cancer and antibiotic drugs with special emphasis on anti-cancer drugs and tissue healing, are discussed in this mini-review.

Keywords:

• Nanogels
• temperature responsive
• drug delivery system
• cancer therapy
• tissue repair

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This article is the result of a research project approved by the Student Research Committee of Kerman University of Medical Sciences No. 401000827, which was carried out with the financial support of the Vice-Chancellor for Research and Technology of the University.