Influence of Binder Type on Interacting Variables Acting on Mechanical Properties of a Sulfadimidine Tablet Formulation

Abstract

A study of the quantitative effect of type of binder (N), applied pressure (P), and granular size (G) on two mechanical properties–tensile strength (TS) and brittle fracture index (BFI)—of a sulfadimidine tablet formulation has been carried out by using a 2³ factorial experimental design. The results obtained from this work suggest that P exhibited the largest individual effect on TS and BFI. It is also seen from this work that the nature of binders in combination affects the influence that P and G had on the TS or BFI.

Keywords:

• binder
• breadfruit starch
• plantain starch
• brittle fracture index
• tensile strength
• sulfadimidine