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Pharmaceutical Development and Technology Volume 13, 2008 - Issue 3
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Research Article

Alginate Inserts Loaded with Epidermal Growth Factor for the Treatment of Keratoconjunctivitis Sicca

Christoph Koelwel Department of Pharmaceutical Technology, University of Regensburg, Germany
,
Stefan Rothschenk Department of Pharmaceutical Technology, University of Regensburg, Germany
,
Barbara Fuchs-Koelwel University Eye Clinic, University of Regensburg, Germany
,
Bernhard Gabler University Eye Clinic, University of Regensburg, Germany
,
Chris Lohmann University Eye Clinic, University of Regensburg, Germany
&
Achim Göpferich Department of Pharmaceutical Technology, University of Regensburg, Germany
Pages 221-231 | Received 12 Jul 2007, Accepted 09 Nov 2007, Published online: 07 Oct 2008
 
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Abstract

We developed and tested ocular inserts containing epidermal growth factor (EGF) for a causal treatment of keratoconjunctivitis sicca (KCS). The inserts, consisting of different alginates with hydroxyethylcellulose (HEC) as a lubricant and release modifier, released EGF over time periods ranging from a few hours up to several days. The stability of EGF was high, having a protein half-life of approximately 548 days. A clinical pilot study suggests an amelioration of both the main symptoms and the objective criteria: tear film break-up (BUT) time and lissamine green score. Our results show that EGF treatment of KCS is highly promising.

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