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Research Article

Formulations for Intermittent Release of Parathyroid Hormone (1-34) and Local Enhancement of Osteoblast Activities

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Pages 505-512 | Received 18 Feb 2008, Accepted 16 Jun 2008, Published online: 20 Oct 2008
 

Abstract

The objective of these studies was to develop simple, implantable devices that intermittently release PTH(1-34) and thus could be used for locally stimulating bone formation. The formulations were based on the association polymer system of cellulose acetate phthalate and Pluronic F-127. Release profiles for intermittent devices showed five discrete peaks, whereas sustained devices exhibited zero-order kinetics. Osteoblastic activity was greater for cells intermittently treated with PTH(1-34) compared to sustained exposure. These controlled release devices delivering PTH(1-34) in an intermittent manner may be useful for affecting osteoblast activities in a localized area.

ACKNOWLEDGMENTS

This work was supported by the Kentucky Science and Education Foundation (KSEF-148-502-03-67) and the National Institutes of Health (AR048700).

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