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Research Article

Mechanism of In Vitro Percutaneous Absorption Enhancement of Carvedilol by Penetration Enhancers

, , , &
Pages 533-539 | Received 07 Mar 2008, Accepted 23 May 2008, Published online: 06 Nov 2008
 

Abstract

The effect of penetration enhancers like tulsi (basil) oil, eucalyptus oil, clove oil, black cumin oil, oleic acid and Tween 80 on the percutaneous absorption of model lipophilic drug-carvedilol was investigated using excised rat abdominal skin. Transdermal flux, permeability coefficient and enhancement factor were calculated for each penetration enhancer. Black cumin oil (5% v/v) was selected on the basis of its highest enhancement in permeation and was evaluated further for its mode of action using DSC, FTIR and histological studies. The results indicated that the oil shows its action by extraction of lipids from stratum corneum as well as by loosening the hydrogen bonds between ceramides subsequently leading to fluidization of the lipid bilayer.

ACKNOWLEDGMENTS

The author (SA) is grateful for financial assistance provided by Council for Scientific and Industrial Research (CSIR), India.

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