Formulation and evaluation of in situ gelling system of dimenhydrinate for nasal administration

Abstract

Nasal drug delivery has a variety of advantages. Drugs can be rapidly absorbed through the nasal mucosa, giving rapid onset of action, and avoiding presystemic metabolism. In present study; the nasal mucoadhesive in situ gels of anti-emetic drug Dimenhydrinate were formulated using Gellan gum and Carbopol 934P. The in situ gels so prepared were characterized for gelation, viscosity, gel strength, mucoadhesion, drug content, drug diffusion, ex vivo permeation and histopathological studies. The optimized formulation passing from above tests was further subjected to accelerated stability study. It retained the good stability over the period of 90 days. From the overall performance this in situ gel seems to be an effective delivery system for the nasal route.

Keyword::

• In situ gel
• nasal drug delivery
• dimenhydrinate
• ionic gelation
• mucoadhesion

Acknowledgments

The authors are grateful to RPG Lifesciences Ltd, India, CpKelco Inc, USA, and Lubrizol Inc., USA, for gener ously providing Gift samples of Dimenhydrinate, Gellan gum and Carbopol 934P NF, respectively.

Declaration of interest: The authors report no conflicts of interest.