97
Views
11
CrossRef citations to date
0
Altmetric
Research Article

Fabrication and design of transdermal fluconazole spray

&
Pages 208-215 | Received 25 Jun 2008, Accepted 22 Sep 2008, Published online: 01 Apr 2009
 

Abstract

The objective of the present study was to formulate fluconazole transdermal spray for obtaining modified drug transport using eutectic mixture, ethyl cellulose, polyethylene oxide and alcohol. The formulated products were characterized. The selection of the optimized batch was done considering the results of drug transport in the first hour, the time required for 90% drug transport, viscosity and spray angle of the formulations. The inclusion of eutectic mixture, consisting of equal parts of camphor and menthol, showed improved drug transport through rat skin. The optimized batch exhibited larger mean zone of inhibition (antifungal activity), efficient in vivo activity and short term stability.

Acknowledgments

We are grateful to the Indian Council of Medical Research (ICMR) for providing senior research fellowship (SRF) to one of the authors for this project. We are thankful to Zydus Cadila (India) for kindly providing the gift samples. We are grateful to Dr Atit Shah of Sarthak Laboratories (Ahmedabad, India) for helping us in carrying out antifungal activity of the samples at his pathological laboratory free of cost. We wish to extend special thanks to Dr Umesh Karia, Dr Belaben Shah and Dr M. M. Prabhakar of Civil Hospital, Ahmedabad, India, for providing guidance in the in vivo study.

Declaration of interest: The authors report no conflicts of interest.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 523.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.