Characterization of acid modified Dioscorea starches as direct compression excipient

Abstract

Starches obtained from four different Dioscorea species namely White (D. rotundata), Bitter (D. dumetorum), Chinese (D. oppositifolia) and Water yam (D. alata), were modified by acid hydrolysis and the physicochemical, material and tablet formation properties of the starches were investigated with the aim of determining their usefulness as a direct compression excipient in pharmaceutical tablets. The results obtained indicate that the physicochemical, material and tablet properties of the acid modified Dioscorea starches varied considerably among the various species. Acid hydrolysis led to an increase in solubility but decrease in swelling of the starches. Acid modification also led to an increase in the compressibility of the starches when compared with the native forms of the starches. Acid modified Water and White formed intact stable tablets only at higher ρ_{rel, max}, while acid modified Chinese and Bitter formed tablets at all relative densities which could already be predicted from the deformation behaviour as analyzed by 3-D modeling. The result indicates that acid modified starch tablets showed higher crushing force and acceptable disintegration time and could therefore be useful as directly compressible excipient.

Keywords::

• Dioscorea starches
• yam
• acid modified starch
• tablet
• compaction properties

Acknowledgments

We gratefully acknowledge the Alexander von Humboldt Foundation for a Georg Forster Fellowship awarded to O. A. Odeku.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.