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Research Article

Transdermal delivery of salbutamol sulphate: Formulation and evaluation

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Pages 216-225 | Received 11 Aug 2008, Accepted 17 Oct 2008, Published online: 01 Apr 2009
 

Abstract

Salbutamol patches were prepared and evaluated. The effect of different Eudragits and various plasticizers on the properties of the patches were studied. Patches were prepared by casting method employing different plasticizers. These patches were evaluated for weight, thickness uniformity, swelling index, tensile strength, elongation percent and moisture absorption capacity. Release was studied. Tensile strength of the patches using Eudragit RS 100 as well as RS100 + L100 and triacetin was the lowest. Formulae containing 10% oleic acid and 5% dimethyl formamide, respectively, showed the highest permeability. These two formulae were studied clinically, the first formula only showed a significant improvement.

Acknowledgments

The authors would like to thank Amoun Co., Cairo, Egypt, for the provision of salbutamol sulphate.

Declaration of interest: The authors report no conflicts of interest.

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