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Pharmaceutical Development and Technology Volume 14, 2009 - Issue 4
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Research Article

Preparation and characterization of Tegafur magnetic thermosensitive liposomes

Zeng ZhaowuNational Hepatobiliary & Enteric Surgery Research Center, Ministry of Health, Central South University; National Key Laboratory of Nanobiological Technology; Institute of Biomedical Engineering of Central South University; Changsha, Hunan
,
Wang XiaoliYichun University of JiangXi Province, Yichun, JiangXi, P.R. China
,
Zhang YangdeNational Hepatobiliary & Enteric Surgery Research Center, Ministry of Health, Central South University; National Key Laboratory of Nanobiological Technology; Institute of Biomedical Engineering of Central South University; Changsha, Hunan
,
Liu XingyanNational Hepatobiliary & Enteric Surgery Research Center, Ministry of Health, Central South University; National Key Laboratory of Nanobiological Technology; Institute of Biomedical Engineering of Central South University; Changsha, Hunan
,
Zhou WeihuaNational Hepatobiliary & Enteric Surgery Research Center, Ministry of Health, Central South University; National Key Laboratory of Nanobiological Technology; Institute of Biomedical Engineering of Central South University; Changsha, Hunan
&
Li NianfengNational Hepatobiliary & Enteric Surgery Research Center, Ministry of Health, Central South University; National Key Laboratory of Nanobiological Technology; Institute of Biomedical Engineering of Central South University; Changsha, HunanCorrespondence[email protected]
Pages 350-357 | Received 12 Jul 2008, Accepted 21 Nov 2008, Published online: 27 Jul 2009
 
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Abstract

The purpose was to study the preparation and properties of tegafur magnetic thermosensitive liposomes. The method was to employ an improved chemical coprecipitation method for preparing nano-magnetic particles and a reverse-phase evaporation and ultrasonic method for preparing tegafur magnetic thermosensitive liposomes. The results showed that tegafur magnetic thermosensitive liposomes were prepared successfully. They had comparatively strong magnetism and superparamagnetism, and their temperature showed a linear positive correlation with dosages and the field strength under a current value. The conclusion was that tegafur magnetic thermosensitive liposomes with comparatively small particle size, superparamagnetism and comparatively strong magnetism were prepared successfully.

Acknowledgments

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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