Complexation of risperidone with a taste-masking resin: Novel application of near infra-red and chemical imaging to evaluate complexes

Abstract

The purpose of the study was to investigate the complexation between a weakly basic drug (risperidone) and an ion exchange resin (amberlite IRP-64) used as a taste-masking agent via two preparation methods: physical mixture and solvent evaporation. Both methods were prepared in different drug-to-resin ratios by weight (1:1, 1:2, 1:4, 1:6). Physicochemical characterizations were performed using differential scanning calorimetry, x-ray diffraction, infra-red spectroscopy, Raman spectroscopy, near infra-red spectroscopy, chemical imaging and drug release studies. These physicochemical techniques revealed that risperidone formed complex with the resin via the solvent evaporation method where enhanced dissolution occurred but not with the physical mixtures.

Keywords::

• Polacrilex
• amberlite
• complexation
• characterization
• drug release
• chemical imaging
• calorimetry (DSC)
• FTIR
• near infra-red spectroscopy
• raman spectroscopy
• x-ray diffractometry

Acknowledgment

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. The opinions expressed in this work are only of authors, and do not necessarily reflect the policy and statements of the FDA.