Gender and interindividual variability in pharmacokinetics

Abstract

Like any other drugs, antiallergic medications can be associated with large inter- and intraindividual variability in their disposition. The best-documented examples belong to the H1 antihistamines. Variable drugs are more likely to show unpredictable therapeutic response with both increased risks of side effects and subtherapeutic dosing in individual subjects. This article will review the main factors contributing to intervariability in pharmacokinetics with a special emphasis on gender differences, genetic polymorphism, and food habits.

Keywords::

• Antihistamines
• cytochrome P-450
• transporters
• gender
• genetic polymorphism
• hormonal effect
• variability
• food

Acknowledgements

Declaration of interest: The authors report no financial conflicts of interest. The authors alone are responsible for the content and writing of this paper.