Senile cataract‐a biochemical approach and in vivo regulation of calcium and phosphate

Abstract

Aqueous humor and lenses from cataractous patients of cortical, nuclear and brunescent types of different age groups from males and females were analysed for their contents of H₂O₂ MDA, Ca⁺⁺ and isoelectric points. The regulation of calcium (in vivo) were studied by using Vit. D., calcitonin and parathyroid hormone. Significant enhancement of H₂O₂, MDA and Ca⁺⁺ was observed in human cataractous lenses and aqueous humor. In vivo studies indicate that any alteration/deviation in Vit.D, calcitonin and parathyroid hormone homeostasis may induce hypo/hypercalcemia and hypo/hyperphosphatemia. The combined effect of these biochemical parameters can lead to damage of ocular tissues.

Key words:

• Cataract
• Cortical
• Nuclear
• Brunescent
• Hydrogen peroxide
• Malonaldehyde
• Calcium

Notes

Corresponding author.