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Summary
Study objective: To compare the efficacy and safety of brodimoprim (BDP) with those of amoxicillin (AMX) in patients with acute bacterial pharyngitis/tonsillitis.
Design: Randomized controlled study.
Setting: Hospital and general practices in Austria, Germany and Switzerland.
Patients: 519 adult patients of both sexes aged 12 to 75 years.
Intervention: Patients were allocated to an 8- to 12-day treatment with BDP (400 mg loading dose followed by 200mg once a day) or AMX (750mg t.i.d).
Main outcome measures: Resolution of clinical signs/ symptoms and negative bacterial examination at completion of therapy.
Results: Clinical cure/improvement rate of 97.8% and 94.896 in respectively the BDP and the AMX group. Bacterial eradication in 87.7% of the cases treated with BDP and 88.3% of those receiving AMX. Very good/good tolerability in 85.2% BDP- and 82.8% AMX treated patients.