Risk factors associated with insufficient and potentially toxic voriconazole plasma concentrations: an observational study

Abstract

The aim of this study was to identify potential factors associated with insufficient/toxic voriconazole trough concentrations (VTCs) in patients in order to screen the high-risk population. A total of 119 VTCs were obtained from 67 patients. Multivariate regression analysis suggested that insufficient VTCs (<1.0 mg/L) were significantly associated with younger age and underlying hematological malignancy, and toxic VTCs (>5.5 mg/L) were significantly associated with lower serum albumin (ALB) level. Receiver operating characteristic curve analysis indicated that patients whose age < 47 years were the high-risk population of insufficient VTCs, and patients whose ALB <27 g/L were the high-risk population of toxic VTCs. Younger age and underlying hematological malignancy were significant predictors of insufficient VTCs, and lower ALB level was found to be a significant predictor of toxic VTCs. Therefore, we recommend to increase the monitoring on these high-risk population to avoid treatment failure and to prevent toxic adverse events.

Keywords:

• Voriconazole
• Risk factor
• Hematological malignancy
• Albumin
• Therapeutic drug monitoring
• ROC curve analysis