https://orcid.org/0000-0003-4270-2687
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Abstract
In the era of antifungal prophylaxis for cancer patients, Fusarium genus has become the second leading cause of invasive fungal infections and mortality in this group of patients. The intrinsic resistance to antifungal agents and the patient’s risk factors are the most important variables for prognosis and survival. Currently, the use of monotherapy in comparison to combined antifungal treatment information is scarce. In this report, we present a series of three cases of children with acute lymphoblastic leukemia and disseminated fusariosis categorized according to the European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG). Furthermore, we present a current literature review focused on treatment using monotherapy or combined antifungal treatment.
Acknowledgment
We thank the Department of Microbiology of the Faculty of Medicine of the Autonomous University of Nuevo León, with whom we participated together for the processing and identification of the isolates and who were committed to the results of this review.
Disclosure statement
The authors declare that there are no conflicts of interest.
Additional information
Notes on contributors
M. P. Riojas Hernández
Riojas- Hernández MP, M.D. Pediatrician trained by the University de Monterrey (UDEM). Infectious Diseases fellow in training at the Hospital Universitario “Dr. José Eleuterio González”, Monterrey, México.
Cisneros - Saldaña D, M.D. Chief of residents of Pediatrics Department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Vaquera-Aparicio DN, M.D. Pediatric Infectious Diseases Professor department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Castillo- Bejarano JI, M.D. Pediatric Infectious Diseases Professor at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Mascareñas de los Santos AH, M.D. Head and Professor of the Pediatric Infectious Diseases department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México. Founding President of the Mexican Association of Vaccination. Vice president of the World Society of Pediatric Infectious Diseases. Former president of Latinamerican Society of Pediatric Infectious Diseases 2017-2019.
Villanueva-Lozano H, M.D. Internal Medicine. Infectious Diseases Subespecialty. Department of Microbiology Professor at the Faculty of Medicine of the Universidad Autónoma de Nuevo León.
Rogelio de J. Treviño Rangel. Medical Micology. Department of Microbiology Professor at the Faculty of Medicine of the Universidad Autónoma de Nuevo León.
M.E. De La O Cavazos, M.D. Pediatrician. Pediatric Internal Medicine Subespecialty. Head of the Department of Pediatrics at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México. Health Secretary and General Director of Health Services in Nuevo León, México.
D. Cisneros Saldaña
Riojas- Hernández MP, M.D. Pediatrician trained by the University de Monterrey (UDEM). Infectious Diseases fellow in training at the Hospital Universitario “Dr. José Eleuterio González”, Monterrey, México.
Cisneros - Saldaña D, M.D. Chief of residents of Pediatrics Department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Vaquera-Aparicio DN, M.D. Pediatric Infectious Diseases Professor department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Castillo- Bejarano JI, M.D. Pediatric Infectious Diseases Professor at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Mascareñas de los Santos AH, M.D. Head and Professor of the Pediatric Infectious Diseases department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México. Founding President of the Mexican Association of Vaccination. Vice president of the World Society of Pediatric Infectious Diseases. Former president of Latinamerican Society of Pediatric Infectious Diseases 2017-2019.
Villanueva-Lozano H, M.D. Internal Medicine. Infectious Diseases Subespecialty. Department of Microbiology Professor at the Faculty of Medicine of the Universidad Autónoma de Nuevo León.
Rogelio de J. Treviño Rangel. Medical Micology. Department of Microbiology Professor at the Faculty of Medicine of the Universidad Autónoma de Nuevo León.
M.E. De La O Cavazos, M.D. Pediatrician. Pediatric Internal Medicine Subespecialty. Head of the Department of Pediatrics at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México. Health Secretary and General Director of Health Services in Nuevo León, México.
D. N. Vaquera Aparicio
Riojas- Hernández MP, M.D. Pediatrician trained by the University de Monterrey (UDEM). Infectious Diseases fellow in training at the Hospital Universitario “Dr. José Eleuterio González”, Monterrey, México.
Cisneros - Saldaña D, M.D. Chief of residents of Pediatrics Department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Vaquera-Aparicio DN, M.D. Pediatric Infectious Diseases Professor department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Castillo- Bejarano JI, M.D. Pediatric Infectious Diseases Professor at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Mascareñas de los Santos AH, M.D. Head and Professor of the Pediatric Infectious Diseases department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México. Founding President of the Mexican Association of Vaccination. Vice president of the World Society of Pediatric Infectious Diseases. Former president of Latinamerican Society of Pediatric Infectious Diseases 2017-2019.
Villanueva-Lozano H, M.D. Internal Medicine. Infectious Diseases Subespecialty. Department of Microbiology Professor at the Faculty of Medicine of the Universidad Autónoma de Nuevo León.
Rogelio de J. Treviño Rangel. Medical Micology. Department of Microbiology Professor at the Faculty of Medicine of the Universidad Autónoma de Nuevo León.
M.E. De La O Cavazos, M.D. Pediatrician. Pediatric Internal Medicine Subespecialty. Head of the Department of Pediatrics at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México. Health Secretary and General Director of Health Services in Nuevo León, México.
J. I. Castillo Bejarano
Riojas- Hernández MP, M.D. Pediatrician trained by the University de Monterrey (UDEM). Infectious Diseases fellow in training at the Hospital Universitario “Dr. José Eleuterio González”, Monterrey, México.
Cisneros - Saldaña D, M.D. Chief of residents of Pediatrics Department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Vaquera-Aparicio DN, M.D. Pediatric Infectious Diseases Professor department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Castillo- Bejarano JI, M.D. Pediatric Infectious Diseases Professor at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Mascareñas de los Santos AH, M.D. Head and Professor of the Pediatric Infectious Diseases department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México. Founding President of the Mexican Association of Vaccination. Vice president of the World Society of Pediatric Infectious Diseases. Former president of Latinamerican Society of Pediatric Infectious Diseases 2017-2019.
Villanueva-Lozano H, M.D. Internal Medicine. Infectious Diseases Subespecialty. Department of Microbiology Professor at the Faculty of Medicine of the Universidad Autónoma de Nuevo León.
Rogelio de J. Treviño Rangel. Medical Micology. Department of Microbiology Professor at the Faculty of Medicine of the Universidad Autónoma de Nuevo León.
M.E. De La O Cavazos, M.D. Pediatrician. Pediatric Internal Medicine Subespecialty. Head of the Department of Pediatrics at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México. Health Secretary and General Director of Health Services in Nuevo León, México.
A. H. Mascareñas de los Santos
Riojas- Hernández MP, M.D. Pediatrician trained by the University de Monterrey (UDEM). Infectious Diseases fellow in training at the Hospital Universitario “Dr. José Eleuterio González”, Monterrey, México.
Cisneros - Saldaña D, M.D. Chief of residents of Pediatrics Department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Vaquera-Aparicio DN, M.D. Pediatric Infectious Diseases Professor department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Castillo- Bejarano JI, M.D. Pediatric Infectious Diseases Professor at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Mascareñas de los Santos AH, M.D. Head and Professor of the Pediatric Infectious Diseases department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México. Founding President of the Mexican Association of Vaccination. Vice president of the World Society of Pediatric Infectious Diseases. Former president of Latinamerican Society of Pediatric Infectious Diseases 2017-2019.
Villanueva-Lozano H, M.D. Internal Medicine. Infectious Diseases Subespecialty. Department of Microbiology Professor at the Faculty of Medicine of the Universidad Autónoma de Nuevo León.
Rogelio de J. Treviño Rangel. Medical Micology. Department of Microbiology Professor at the Faculty of Medicine of the Universidad Autónoma de Nuevo León.
M.E. De La O Cavazos, M.D. Pediatrician. Pediatric Internal Medicine Subespecialty. Head of the Department of Pediatrics at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México. Health Secretary and General Director of Health Services in Nuevo León, México.
H. Villanueva-Lozano
Riojas- Hernández MP, M.D. Pediatrician trained by the University de Monterrey (UDEM). Infectious Diseases fellow in training at the Hospital Universitario “Dr. José Eleuterio González”, Monterrey, México.
Cisneros - Saldaña D, M.D. Chief of residents of Pediatrics Department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Vaquera-Aparicio DN, M.D. Pediatric Infectious Diseases Professor department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Castillo- Bejarano JI, M.D. Pediatric Infectious Diseases Professor at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Mascareñas de los Santos AH, M.D. Head and Professor of the Pediatric Infectious Diseases department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México. Founding President of the Mexican Association of Vaccination. Vice president of the World Society of Pediatric Infectious Diseases. Former president of Latinamerican Society of Pediatric Infectious Diseases 2017-2019.
Villanueva-Lozano H, M.D. Internal Medicine. Infectious Diseases Subespecialty. Department of Microbiology Professor at the Faculty of Medicine of the Universidad Autónoma de Nuevo León.
Rogelio de J. Treviño Rangel. Medical Micology. Department of Microbiology Professor at the Faculty of Medicine of the Universidad Autónoma de Nuevo León.
M.E. De La O Cavazos, M.D. Pediatrician. Pediatric Internal Medicine Subespecialty. Head of the Department of Pediatrics at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México. Health Secretary and General Director of Health Services in Nuevo León, México.
J. Treviño-Rangel Rogelio de
Riojas- Hernández MP, M.D. Pediatrician trained by the University de Monterrey (UDEM). Infectious Diseases fellow in training at the Hospital Universitario “Dr. José Eleuterio González”, Monterrey, México.
Cisneros - Saldaña D, M.D. Chief of residents of Pediatrics Department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Vaquera-Aparicio DN, M.D. Pediatric Infectious Diseases Professor department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Castillo- Bejarano JI, M.D. Pediatric Infectious Diseases Professor at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Mascareñas de los Santos AH, M.D. Head and Professor of the Pediatric Infectious Diseases department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México. Founding President of the Mexican Association of Vaccination. Vice president of the World Society of Pediatric Infectious Diseases. Former president of Latinamerican Society of Pediatric Infectious Diseases 2017-2019.
Villanueva-Lozano H, M.D. Internal Medicine. Infectious Diseases Subespecialty. Department of Microbiology Professor at the Faculty of Medicine of the Universidad Autónoma de Nuevo León.
Rogelio de J. Treviño Rangel. Medical Micology. Department of Microbiology Professor at the Faculty of Medicine of the Universidad Autónoma de Nuevo León.
M.E. De La O Cavazos, M.D. Pediatrician. Pediatric Internal Medicine Subespecialty. Head of the Department of Pediatrics at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México. Health Secretary and General Director of Health Services in Nuevo León, México.
M. E. De la O Cavazos
Riojas- Hernández MP, M.D. Pediatrician trained by the University de Monterrey (UDEM). Infectious Diseases fellow in training at the Hospital Universitario “Dr. José Eleuterio González”, Monterrey, México.
Cisneros - Saldaña D, M.D. Chief of residents of Pediatrics Department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Vaquera-Aparicio DN, M.D. Pediatric Infectious Diseases Professor department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Castillo- Bejarano JI, M.D. Pediatric Infectious Diseases Professor at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Mascareñas de los Santos AH, M.D. Head and Professor of the Pediatric Infectious Diseases department at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México. Founding President of the Mexican Association of Vaccination. Vice president of the World Society of Pediatric Infectious Diseases. Former president of Latinamerican Society of Pediatric Infectious Diseases 2017-2019.
Villanueva-Lozano H, M.D. Internal Medicine. Infectious Diseases Subespecialty. Department of Microbiology Professor at the Faculty of Medicine of the Universidad Autónoma de Nuevo León.
Rogelio de J. Treviño Rangel. Medical Micology. Department of Microbiology Professor at the Faculty of Medicine of the Universidad Autónoma de Nuevo León.
M.E. De La O Cavazos, M.D. Pediatrician. Pediatric Internal Medicine Subespecialty. Head of the Department of Pediatrics at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, México. Health Secretary and General Director of Health Services in Nuevo León, México.