Abstract
This study aimed to investigate the regulatory relationship between miR-144-3p and COL11A1, and to explore its effect on the proliferation, migration and invasion of lung adenocarcinoma (LUAD) cells. A series of methods and experiments were applied. miR-144-3p was downregulated in LUAD tissue and cells, whereas COL11A1 was highly expressed. Overexpressing miR-144-3p inhibited the proliferation, migration and invasion of LUAD cells, which could be reversed by overexpression of COL11A1. Overexpressing miR-144-3p inhibits the proliferation, migration and invasion of LUAD cells by silencing COL11A1.
Acknowledgments
The authors are very grateful for the contributions of the TCA Network, targetScan Network, starBase Network and mirDIP Network. The authors thank patients who have participated in TCGA, targetScan, starBase and mirDIP. The authors sincerely thank the researchers for providing their TCGA, targetScan, starBase and mirDIP database information online, and we are pleased to recognize their contribution.
Disclosure statement
The author claims that there is no conflict of interest.
Data availability statement
Data can be accessed through links https://portal.gdc.cancer.gov/, http://www.targetscan.org/vert_72/, http://starbase.sysu.edu.cn/ and http://ophid.utoronto.ca/mirDIP/index.jsp#r.
Additional information
Funding
Notes on contributors
Yahong Sun
Yahong Sun holds a “Bachelor” degree and works in the Department of Respiratory and Critical Care Medicine, Haining People's Hospital. Her research interests mainly include standardized treatment of chronic cough, asthma and chronic obstructive pulmonary disease, diagnosis and treatment of difficult critical diseases in respiratory department, and pulmonary imaging.
Zhihao Liu
Zhihao Liu holds a “Bachelor” degree and works in the Department of Respiratory and Critical Care Medicine, Haining People's Hospital. He has been engaged in clinical work for ten years. He has rich clinical experience in all kinds of diseases in respiratory department. His research interests include diagnosis and treatment of respiratory diseases such as pneumonia, lung cancer, chronic obstructive pulmonary disease, bronchial asthma, bronchiectasis, etc. He is skilled in bronchoscopy interventional therapy, CT-guided lung puncture biopsy, CT-guided radiofrequency ablation of lung mass, and medical thoracoscopy.
Lifei Huang
Lifei Huang holds a “master” degree and works in the Department of Respiratory and Critical Care Medicine, Haining People's Hospital. Research interests include asthma, COPD, chronic cough, lung cancer and other respiratory diseases.
Yan Shang
Yan Shang holds a “MD” degree and works in Changhai Hospital, Naval Medical University. Her research interests include the diagnosis and treatment of asthma and chronic cough and asthma diseases, early diagnosis and multidisciplinary treatment of lung tumors, and interventional diagnosis and treatment via bronchoscopy.