Relationship between renal dysfunction and electrolyte abnormalities in hematopoietic stem cell transplant patients treated with foscarnet

Abstract

This study aimed to investigate the relationship between renal dysfunction and electrolyte abnormalities, which are adverse events of foscarnet used for cytomegalovirus infection. Of the Ninety hematopoietic stem cell transplantation patients, 32 who met the selection criteria were enrolled in this retrospective study. The study patients were divided into two groups according to whether they developed renal dysfunction. The incidences of hypocalcemia, hypokalemia, and hypomagnesemia with an increase of grade 2 or higher in the renal dysfunction group were 45.5%, 18.2%, and 27.3%, respectively. Additionally, in the renal dysfunction group, a significant correlation was observed between creatinine and calcium (r = −0.458, p = 0.0244) and between creatinine and potassium (r = −0.520, p = 0.0092). This study shows that renal dysfunction and electrolyte abnormalities may be closely related in HSCT patients receiving foscarnet; thus, it is a report that may contribute to the safety of continuous foscarnet treatment.

Keywords:

• Foscarnet
• renal dysfunction
• electrolyte abnormalities
• hematopoietic stem cell transplantation patients
• hypocalcemia
• hypokalemia
• hypomagnesemia

Disclosure statement

No potential conflict of interest was reported by the author(s).

Author contributions

R.O. had full access to all of the data in this study; took responsibility for the integrity of the data; and contributed to the conceptual design of the study, data collection and analyses, interpretation of the data, and writing of the manuscript. A.H. contributed to the conceptual design of the study, data analyses, interpretation of the data, and review of the manuscript.

Additional information

Notes on contributors

Ryosuke Ota

Ryosuke Ota has PhD degree. He is working at Department of Pharmacy, Kindai University Nara Hospital as a Pharmacist.

Atsushi Hirata

Atsushi Hirata has PhD degree. He is working at Department of Pharmacy, Kindai University Nara Hospital as a Pharmacist.