Syndroma Hypereosinophilicum—Case Report and Review

ABSTRACT

There are three categories of blood eosinophilia: reactive (non-clonal), clonal and Idiopathic hypereosinophilic syndrome (HES). The empirical diagnostic criteria of HES are: blood eosinophilia exceeding 1.5×10⁹/l for more than six consecutive months; absence of an underlying cause of hypereosinophilia despite extensive diagnostic evaluation and organ damage or dysfunction as a result of local release of toxic eosinophil substances. We present a patient who fulfills the diagnostic criteria of HES and demonstrates disseminated, multiple, erythematous, pruritic papules on the trunk and extremities and Raynaud's phenomenon as a rare cutaneous manifestation of the disease. The patient was successfully treated with systemic corticosteroids and no evidence of haematological disorder were found.