Correlation between Serum Levels of Interleukin-1β, Interleukin- 1RA, Interleukin-6, Interleukin-10, Interleukin 12, Tumor Necrosis Factor-α and Interferon-γ with some Clinical and Laboratory Parameters in Patients with Salmonellosis

ABSTRACT

Salmonella bacteria are the major cause of food-borne infectious diarrhea. There is great interest in understanding the pathogenesis and immunogenesis of Salmonella infection. Cytokines are key communicator molecules between host cells and the enteric pathogen Salmonella. Serum levels of IL-1, IL-lra, IL-6, IL-10, IL-12, TNF-α and IFN-γ were studied in a prospective controlled study including 36 patients at the acute stage of gastrointestinal salmonellosis. Correlation between them was investigated, as well as between cytokines, body temperature and serum levels of Na⁺, K⁺ and Cl⁻. The lowest correlation was found between TNF-α and IL-1ra. A significant and directly proportional correlation was established between IL-12 with IFN-γand TNF-α, as well as in TNF-α/IL-1 β and IL-1β/IL-1ra. The increased body temperature correlated significantly with IL-1β, TNF-α and IL-6. Significant but converse was the correlation between Na⁺ with IL-1β and IL-6, as well as between body temperature with Na⁺, K⁺ and Cl⁻. Our data imply evidence for the complicated network in which cytokines act with multiple potential synergistic and antagonistic effects between them participating in the main pathogenetic processes—intoxication and loss of fluids and electrolytes.