Targeted treatment of anaerobic cancer. Patent evaluation of US2016279084 and US2017056350

ABSTRACT

Introduction: Based on the initial studies of J. Folkman in 1970s, which led to the proposal of the antiangiogenic therapy, many drugs targeting VEGF or its receptors have been developed with some of them approved for cancer treatment. However, these molecules so far have shown only a limited effect on survival benefits in patients. Thus, new approaches are needed to treat this disease. Considering that cancer utilizes both aerobic and anaerobic glycolytic pathway, authors of patents US2016279084 and US2017056350 propose a method to eradicate the disease, able to affect both metabolic pathways.

Areas covered: Patent US2016279084 describes a method consisting of the utilization of either a pharmaceutical cocktail containing antiglycolytic agents (a lactate transporter inhibitor and a NKCC inhibitor) and an angiogenesis inhibitor or a pharmaceutical cocktail containing a lactate transporter inhibitor and an angiogenesis inhibitor in combination with blood vessel occlusion. Patent US2017056350 is strictly related to US2016279084; indeed, it proposes a method consisting of blood vessel occlusion and treatment with a pharmaceutical cocktail, containing the carbonic anhydrase inhibitor bumetanide in presence or absence of an angiogenesis inhibitor.

Expert opinion: Although the proposed methodology is very interesting and promising, further studies are necessary to assess the clinical applicability of the inventions.

KEYWORDS:

• Angiogenesis
• glycolysis
• carbonic anhydrase IX
• lactate
• ALPHA hypothesis
• pharmaceutical cocktail

Declaration of interest

The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

This work was supported by a grant from CNR-DSB ProgettoBandiera ‘InterOmics.’