Selective COX-2 inhibitors as anticancer agents: a patent review (2018-2023)

ABSTRACT

Introduction

COX-2 is a crucial enzyme in the manufacture of prostaglandins. The enzyme’s metabolites might have an important function as regulators of the inflammatory response and other medical conditions such as cancer. Selective COX-2 inhibitors are believed to enhance or reverse the response of cancer chemotherapeutics.

Areas covered

This study addresses the chemical structures as well as the antitumor activity of new COX-2 inhibitors produced in the recent five years, aiming to provide an insight into the mechanism of COX-2 induced PGE₂ powerful signal in cancer development.

Expert opinion

The significance of selective COX-2 inhibitors as an efficient superfamily of compounds with anti-inflammatory, anti-Alzheimer’s, anti-Parkinson’s disease, and anticancer properties has piqued the passion of academics in the field of drug development. Long-term usage of selective COX-2 inhibitors, such as celecoxib has been proven in clinical trials to lower the incidence of several human malignancies. Furthermore, celecoxib has the potential to greatly increase the effectiveness of chemotherapy. Our extensive understanding of selective COX-2 inhibitor SAR may aid in the development of safer and more effective selective COX-2 inhibitors as cancer chemopreventive agents. This review focuses on the different structural classes of selective COX-2 inhibitors, with a particular emphasis on their SAR.

GRAPHICAL ABSTRACT

KEYWORDS:

• COX-2 enzyme
• COX-2 inhibitors
• cancer
• SAR
• Inflammation

Article highlights

• Cancer is a complicated process that produces several inflammatory mediators.

• COX-2 inhibitors may suppress COX-2, hence potentially treating cancer.

• Selective COX-2 inhibitors are less likely to cause negative effects compared to conventional NSAIDs.

• The consequences of new synthetic analogs being used as selective COX-2 inhibitors are discussed in the current review study.

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

This paper was not funded.