Circulating endothelium-enriched microRNA-126 as a potential biomarker for coronary artery disease in type 2 diabetes mellitus patients

Abstract

Circulating microRNAs (miRNAs) have been shown as promising biomarkers for various diseases. We investigated the predictive potential of circulating endothelium-enriched miR-126 in type 2 diabetes patients (T2D) without chronic complications and T2D patients with coronary artery diseases (CAD). The expression levels of circulating miR-126, determined by quantitative real time PCR, were decrease in peripheral blood of T2D patients and T2D with CAD compared with healthy controls. MiR-126 strongly associated with T2D and CAD, negatively correlated with LDL in CAD patients and differentiated between T2D patients, T2D patients with CAD and healthy subjects. Circulating miR-126 may serve as a biomarker for predicting patients with T2D and diabetic CAD.

Keywords:

• Biomarker
• circulating miR-126
• coronary artery disease
• microRNAs
• type 2 diabetes

Acknowledgements

We would like to acknowledge the staff of the Clinical Laboratory of King Abdullah University Medical City in the Kingdom of Bahrain, the participants in the study and the technical staff at Al-Jawhara Center.

Disclosure statement

The authors report no declarations of interest.

Funding information

This work was supported by a research Grant (No. 81) by the College of Medicine and Medical Sciences, Arabian Gulf University, Kingdom of Bahrain.