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Biomarkers Volume 22, 2017 - Issue 1
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Research Article

Sex hormone-binding globulin and thrombin generation in women using hormonal contraception

Justine Hugon-RodinInserm, UMR 1018, Villejuif, France; ;Gynecology Endocrinology Unit, Port-Royal Hospital, Paris, France; ;Faculté de Médecine Paris Descartes, Hôpital Universitaire Paris Centre, Paris, France; Correspondence[email protected]
,
Martine Alhenc-GelasHematology Unit, AP-HP HEGP, Paris, France;
,
H. Coenraad HemkerBiochemistry, Maastricht University, Maastricht, Netherlands;
,
Sylvie Brailly-TabardService de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Hôpital Bicêtre, APHP, Le Kremlin-Bicêtre, France; ;Inserm, UMR_S1185, Université Paris-Sud, IFR Bicêtre, France
,
Anne Guiochon-MantelService de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Hôpital Bicêtre, APHP, Le Kremlin-Bicêtre, France; ;Inserm, UMR_S1185, Université Paris-Sud, IFR Bicêtre, France
,
Geneviève Plu-BureauInserm, UMR 1018, Villejuif, France; ;Gynecology Endocrinology Unit, Port-Royal Hospital, Paris, France; ;Faculté de Médecine Paris Descartes, Hôpital Universitaire Paris Centre, Paris, France;
&
Pierre-Yves ScarabinInserm, UMR 1018, Villejuif, France;
show all
Pages 81-85 | Received 15 Apr 2016, Accepted 07 Jun 2016, Published online: 06 Jul 2016
 
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Abstract

Objectives: We investigated the impact of serum sex hormone-binding globulin (SHBG) on thrombin generation (TG) in women according to hormonal contraception.

Patients and methods: A cross-sectional study of SHBG and TG measured via calibrated automated thrombography was conducted in 150 healthy women, including 75 users of combined oral contraceptives (COC), 22 users of progestin-only contraceptives (POC) and 53 nonusers.

Results: COC but not POC-users had significantly higher SHBG levels compared with nonusers. In hormonal contraceptive users, SHBG was positively associated with both activated protein C (APC) resistance and baseline TG, and protein S and prothrombin were important mediators.

Conclusion: These data provide further evidence that SHBG may be used as a biomarker in assessing prothrombotic profile of hormonal contraception.

Acknowledgments

We thank Francoise Terrier for her technical assistance.

Disclosure statement

The authors report no declarations of interest.

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