Resistin may be an independent predictor of subclinical atherosclerosis formale smokers

Abstract

To investigate whether resistin is associated with early atherosclerosis in male smokers. The present study consecutively enrolled 50 male smokers. Their serum resistin contents were detected with enzyme linked immunosorbent assay (ELISA), and subclinical atherosclerosis indices, including carotid inner middle thickness (IMT) and arterial elasticity indices (C1 and C2), were measured. The association between serum resistin levels and IMT, C1 and C2 were respectively evaluated with the Pearson’s correlation coefficient method. The results showed that the serum resistin level had a positive association with IMT (r = 0.307, p = .030), but were both inversely associated with C1 (r = −0.440, p = .001) and C2 (r = −0.381, p = .006). These associations remained significant even after adjustment for cardiovascular confounders. In conclusion, serum resistin concentration was independently associated with early atherosclerosis in male smokers.

Keywords:

• Resistin
• atherosclerosis
• smoking
• intima media thickness
• arterial elasticity

Acknowledgements

This work is supported by the National Natural Science Foundation of China (No. 81200242, Li-Hong FAN is the project leader), the Shaanxi Science and Technology Plan Projects (No. 2010K15-05-02, Li-Hong FAN is the project leader) and the Fundamental Research Funds for the Central Universities of Xi’an Jiao Tong University (No. Xjj2010012, Li-Hong FAN is the project leader).

Disclosure statement

There is no conflict of interest to disclose in the manuscript. All authors have seen and approved the study submitted.