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Biomarkers Volume 22, 2017 - Issue 5
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Research Article

Nickel exposure and plasma levels of biomarkers for assessing oxidative stress in nickel electroplating workers

Yu-Chung TsaoDepartment of Occupational Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ;Department of Occupational Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan; ;Department of Family Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ;College of Medicine, Chang Gung University, Taoyuan, Taiwan; ORCID Iconhttp://orcid.org/0000-0001-7355-5208
ORCID Icon,
Po-Wen GuCollege of Medicine, Chang Gung University, Taoyuan, Taiwan; ;Department of Laboratory Medicine, Chang Gung Medical Center, Taoyuan, Taiwan;
,
Su-Hsun LiuDepartment of Family Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ;College of Medicine, Chang Gung University, Taoyuan, Taiwan; ORCID Iconhttp://orcid.org/0000-0002-1151-7983
ORCID Icon,
I-Shiang TzengDepartment of Emergency Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ;Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, TaiwanORCID Iconhttp://orcid.org/0000-0002-9047-8141
ORCID Icon,
Jau-Yuan ChenDepartment of Family Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ;College of Medicine, Chang Gung University, Taoyuan, Taiwan;
&
Jiin-Chyuan John LuoDepartment of Occupational Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ;College of Medicine, Chang Gung University, Taoyuan, Taiwan; Correspondence[email protected]
Pages 455-460 | Received 09 Jun 2016, Accepted 22 Oct 2016, Published online: 10 Nov 2016
 
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Abstract

Context: The mechanism of nickel-induced pathogenesis remains elusive.

Objective: To examine effects of nickel exposure on plasma oxidative and anti-oxidative biomarkers.

Materials and methods: Biomarker data were collected from 154 workers with various levels of nickel exposure and from 73 controls. Correlations between nickel exposure and oxidative and anti-oxidative biomarkers were determined using linear regression models.

Results: Workers with a exposure to high nickel levels had significantly lower levels of anti-oxidants (glutathione and catalase) than those with a lower exposure to nickel; however, only glutathione showed an independent association after multivariable adjustment.

Discussion and conclusion: Exposure to high levels of nickel may reduce serum anti-oxidative capacity.

Disclosure statement

The authors have declared no conflicts of interest.

Funding

This work was supported by NSC 85-2331-B-182-106; NSC94-2314-B182-015; NSC95-2314-B182-054-MY2 to JCL.

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