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Abstract
Context: Acute or chronic exposure of N,N-dimethylacetamide (DMAc) is responsible for abnormal liver function. It appears that DMAc is mainly metabolized by cytochrome P450 in the liver and thereby produces reactive oxygen species (ROS). The elimination of ROS and the repairing of ROS-induced DNA damage are relevant to the ultimate toxicity of DMAc.
Objective: To investigate whether the polymorphisms in the CAT (rs564250, rs769214 and rs7943316), hOGG1 (rs2072668 and rs159153) and XRCC1 (rs25487 and rs1799782) genes are associated with susceptibility to DMAc-induced abnormal liver function in Chinese population.
Methods: Samples were obtained from 108 workers with DMAc-induced abnormal liver function and 108 workers with normal liver function.
Results: Subjects with the CAT rs769214 GA/GG genotypes had a reducing risk of abnormal liver function, which was more evident in the subgroups exposed to DMAc <10 years, exposed to DMAc <5 mg/m3, never smoked and never drank.
Conclusions: CAT rs769214 (-844 G > A) polymorphism may be associated with DMAc-induced abnormal liver function in Chinese population.
Disclosure statement
The authors report that they have no conflicts of interest.
Clinical significance
Many workers are exposed to DMAc in China along with the increasing tendency of DMAc’s production and application. Acute or long-term exposure to DMAc mainly cause liver injury (morphological and functional alterations).Our study is to clarify the correlations between polymorphisms of CAT, hOGG1 and XRCC1 and susceptibility to DMAc-induced abnormal liver function, to provide a theoretical basis for the prevention and clinical treatment of occupational DMAc-induced abnormal liver function.