282
Views
20
CrossRef citations to date
0
Altmetric
Original Articles

Biomarkers of neurotoxicity, oxidative stress, hepatotoxicity and lipid peroxidation in Clarias gariepinus exposed to melamine and polyvinyl chloride

ORCID Icon, , , , &
Pages 603-610 | Received 05 Jul 2020, Accepted 29 Aug 2020, Published online: 22 Sep 2020
 

Abstract

Purpose

Plastic particulates and chemicals are emerging environmental pollutants with significant impact on aquatic ecosystems. In this study, the effects of oral uptake of melamine, melamine formaldehyde, and polyvinyl chloride on serum biochemical profiles, antioxidant enzymes activities, lipid peroxidation levels and brain acetyl cholinesterase activities in Clarias gariepinus juveniles were investigated.

Methods

Fish specimens were fed diets spiked with melamine, melamine formaldehyde and poly vinyl chloride at 0.3% (3.0 g Kg−1) dietary inclusion for 45 days. Toxicity effect of these plastic chemicals was estimated by assaying relevant biomarkers.

Results

After 45 days exposure, Serum glucose was significantly elevated, whereas plasma protein levels were substantially reduced in the exposed fish groups. Serum transaminases were significantly elevated in the exposed groups. Brain acetylcholinesterase and antioxidant enzyme activities declined significantly, while malondialdehyde levels were elevated in the exposed groups.

Conclusion

C. gariepinus is an important bioindicator to monitor the ecotoxicological impact of plastic chemicals such as melamine, and polyvinyl chloride.

Acknowledgements

The authors are grateful to the Department of Fisheries and Aquaculture, Alex Ekwueme Federal University Ndufu-Alike Ikwo, for providing space for this experiment and assisting them with some laboratory equipment during the experiment.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This research was supported by Tertiary Education trust fund (Tetfund), Nigeria.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 527.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.