Au-TiO₂ nanoparticles exposure induced oxidative stress and neurotoxicity in rat

Abstract

Context

The Au-TiO₂NPs have a wide range of applications and can easily enter the cells. Due to their properties, they can cause toxicity.

Objective

It was aimed to test the toxic effects of Au-TiO₂ NPs in the brain, heart, kidney and liver of rats in this work.

Materials and methods

All used rats in this work were treated using diverse concentrations (doses) of NPs (100 and 200 mg/kg bw) for 21 days. SOD, CAT, AChE activities and MDA, H₂O₂, NO contents were evaluated in different organs.

Results

The Au-TiO₂ NPs exposure induced biochemical changes in different organs of rats in view of oxidative stress and neurotoxicity by the alteration of the activity of the enzyme of neurotransmitter (AChE activity).

Conclusion

The Au-TiO₂ NPs have the potential to interact with rat’s biochemical status and cause undesirable effects. One of those damaging effects was oxidative stress and neurotoxicity.

Clinical significance

The study signifies the impact of usage of Au-TiO₂ NPs in the medical field for further exploration.

Keywords:

• Nanoparticles
• Au-TiO₂
• oxidative stress
• neurotoxicity
• NO metabolite
• AChE

Acknowledgements

Taif University Researchers Supporting Project number (TURSP-2020/28), Taif University, Taif, Saudi Arabia.

Disclosure statement

No potential conflict of interest was reported by the author(s).