https://orcid.org/0000-0002-3235-9558
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Abstract
Background
Previous cross-sectional studies have shown that several circulating microRNA levels are associated with hypertension, but there are no prospective studies among general populations.
Objective
We evaluated the impact of circulating inflammatory- and oxidative stress-responsive microRNAs on changes in blood pressure and the development of hypertension in normotensive Japanese.
Method
The study subjects were 84 normotensive participants (33 men and 51 women) who were given a health examination in both 2012 and 2017. In five years, 29 participants developed hypertension. Serum levels of miRNAs (miR-21, miR-27a, and miR-133a) were measured using qRT-PCR. Odds ratios (ORs) and 95% confidence intervals (CIs) for incident hypertension were estimated by logistic regression analysis.
Results
Serum miR-27a and -133a levels were lower in newly hypertensive subjects compared with normotensive subjects. With 1-unit lower serum miR-27a and -133a, the confounders adjusted ORs and 95% CI for incident hypertension were 0.84 (0.72–0.96) and 0.75 (0.58–0.91), respectively. The group with high levels of serum miR-27a and -133a had lower ORs than the group with low levels of these miRNAs (OR and 95% CI of miR-27a: 0.29, 0.08–0.91; miR-133a: 0.08, 0.01–0.37, respectively).
Conclusions
Circulating miR-27a and -133a are potential biomarkers for the prediction and prevention of hypertension.
Acknowledgements
We thank all the study participants and staff involved in the health examinations conducted in Yakumo, Hokkaido, Japan.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Data availability statement
The data that support the findings of this study are available on reasonable request from the corresponding author, KS. The data are not publicly available due to their containing information that could compromise the privacy of research participants.