20
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Cerebrospinal fluid CD4+ T cells from a multiple sclerosis patient cross-recognize Epstein-Barr virus and myelin basic protein

, &
Pages 278-283 | Published online: 10 Jul 2009
 

Abstract

Epstein-Barr virus–specific CD4+ T cells could be involved in the pathogenesis of multiple sclerosis, provided they can gain entry to the intrathecal compartment. The authors have previously demonstrated that cerebrospinal fluid T cells from multiple sclerosis patients recognize autologous Epstein-Barr virus–transformed B cells. They now report that CD4+ T cells specific for the Epstein-Barr virus DNA polymerase peptide EBV 627–641 were present in the cerebrospinal fluid from one of two multiple sclerosis patients, and that a high proportion of these CD4+ T cells cross-recognized an immunodominant myelin basic protein peptide, MBP 85–99. In the observed patient, the proportion of EBV 627–641–specific CD4+ T cells seemed to exceed 1/10 000 in cerebrospinal fluid, compared to approximately 1/100 000 in blood. These findings prove that Epstein-Barr–virus specific CD4+ T cells can gain access to the intrathecal compartment, and suggest that Epstein-Barr virus–specific CD4+ T cells could target myelin basic protein in the central nervous system.

Log in via your institution

Log in to Taylor & Francis Online

There are no offers available at the current time.

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.