Abstract
Low CD4 lymphocyte count was a marker for neurological disease in human immunodeficiency virus type 1 (HIV-1); but is now less common among patients with access to highly active antiretroviral therapy. In this study, the authors determine the reliability of self-reported CD4 nadir and its predictive value for neurological status. The authors identify a high degree of reliability (r = .90). After adjusting for age, current CD4 count, and duration of HIV-1, CD4 nadir relates to a current diagnosis of HIV-associated dimentia (HAD) (odds ratio [OR]: 1.395 (1.106–1.761), P = .005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221–1.769, P < .001).
This work was supported by NINDS grant 1U54NS4349 with additional support from P20 RR11091 (NCRR), RCMI grant G12 RR/AI 03061 (NCRR), and the Hawaii Medical Student Aging Research National Training Center (NIA, John A. Hartford Foundation, and AFAR grant) (P.Y.). The authors are grateful for the assistance of the Hawaii Seropositivity and Medical Management (HSPAMM) program of the Hawaii Department of Heath, our research participants, and community advisors.