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Abstract
In a former study of a patient with cerebellar agenesis (HK) mild motor deficits, problems in delay eyeblink conditioning and mild to moderate deficits in IQ, planning behavior, visuospatial abilities, visual memory, and attention were found. The present study reports additional findings in the same patient. In the motor domain, impairments in fine motor manipulations, trace eyeblink conditioning and motor imagination in a functional magnetic resonance (fMRI) study were found. Based on fMRI findings; however, cortical areas involved in a tapping task did not significantly differ from a healthy control group. In the cognitive domain, deficits in speech comprehension as well as verbal learning and declarative memory were present. No significant affective symptoms were observed. Although problems in executive, visuospatial and language tasks are in agreement with the so-called cerebellar cognitive affective syndrome—other possibilities remain. Non-motor impairments in HK might also be a consequence of lacking motor abilities in development and motor deficits may interfere with the performance of parts of the cognitive tasks. In addition, lack of promotion and learning opportunities in childhood may contribute and mental retardation based on extracerebellar dysfunction cannot be excluded.
We would like to thank HK for her time and effort, B. Brol and S. Sturm for conducting the conditioning experiment, B. Müller for providing the MLS, and H.G. Elles for his help in setting up the fMRI-experiment. The study was supported by a grant of the Deutsche Forschungsgemeinschaft (DFG Ti 239/5-1, DFG Ti 239/5-2).
Notes
We would like to thank HK for her time and effort, B. Brol and S. Sturm for conducting the conditioning experiment, B. Müller for providing the MLS, and H.G. Elles for his help in setting up the fMRI-experiment. The study was supported by a grant of the Deutsche Forschungsgemeinschaft (DFG Ti 239/5-1, DFG Ti 239/5-2).
Merk M., Entwicklung und Implementierung PC-gestützter akustischer Analyseverfahren für die klinische Diagnostik neurogener Sprechstörungen. Dissertation, Universität der Bundeswehr München2002