Rapid Relief of Thalamic Pain Syndrome Induced by Vestibular Caloric Stimulation

Abstract

Central post-stroke pain syndrome develops in a minority of patients following a stroke. The most usual causative lesion involves the lateral thalamus. The classic presentation is of severe, unrelenting pain that involves the entire contralateral half of the body. It is largely refractory to current treatments. We found that in two patients with this condition their pain was substantially improved by vestibular caloric stimulation, whereas placebo procedures had no effect. We proposed that this is because vestibular stimulation activates the posterior insula, which in turn inhibits the generation of pain in the anterior cingulate.

Keywords:

• Dejerine–Roussy syndrome
• thalamic pain
• central pain
• post-stroke pain
• vestibular stimulation
• insula
• anterior cingulate
• thalamus
• stroke

Our work is funded by the R. Geckler and the C. Robbins Foundations. However neither funding source had any role in the design or execution of this study.