Advanced search
Publication Cover
Neurocase
Behavior, Cognition and Neuroscience
Volume 17, 2011 - Issue 6
Submit an article Journal homepage
308
Views
8
CrossRef citations to date
0
Altmetric
Original Articles

Long-term time course of affective lability after subthalamic deep brain stimulation electrode implantation

Lars Wojtecki Institute of Clinical Neuroscience and Medical Psychology & Department of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty, Heinrich-Heine-University Düsseldorf, GermanyCorrespondence[email protected]
,
Lars Timmermann Department of Neurology, University of Cologne, Cologne, Germany
,
Stefan Jun Groiss Institute of Clinical Neuroscience and Medical Psychology & Department of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany
,
Saskia Elben Institute of Clinical Neuroscience and Medical Psychology & Department of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany
,
Christiane Reck Department of Neurology, University of Cologne, Cologne, Germany
,
Martin Südmeyer Institute of Clinical Neuroscience and Medical Psychology & Department of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany
,
Volker Sturm Department of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne, Germany
&
Alfons Schnitzler Institute of Clinical Neuroscience and Medical Psychology & Department of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany
 show all
Pages 527-532 | Received 15 Jul 2010, Accepted 04 Nov 2010, Published online: 27 Jun 2011
 
Sample our Behavioral Sciences journals, sign in here to start your access, latest two full volumes FREE to you for 14 days

Abstract

The mechanism and time course of emotional side effects of subthalamic deep brain stimulation in Parkinson's disease are a matter for discussion. We report a 53-month follow-up of a patient with affective lability. Postoperative lesion plus bilateral stimulation strongly influenced mood in the first week in terms of laughing behavior, while voltage changes had only minor long-term impact up to 37 months on negative emotion, possibly caused by the right electrode stimulating the subthalamic nucleus and adjacent fiber tracts involving the internal capsule. Thus we conclude that affective lability can occur with different temporal dynamics of microlesion, and early and chronic stimulation.

Acknowledgments

The authors thank the patient for his excellent cooperation.

Funding: Lars Wojtecki was supported by a grant of the ‘Forschungskommission’ of the Medical Faculty HHU Düsseldorf.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 53.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 439.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.