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Behavior, Cognition and Neuroscience
Volume 18, 2012 - Issue 2
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Original Articles

Exploring the relationship between white matter microstructure and working memory functioning following stroke: A single case study of computerized cognitive training

Jan E. Nordvik Centre for the Study of Human Cognition, Department of Psychology, University of Oslo, NorwayCorrespondence[email protected]
,
Anne-Kristine Schanke Centre for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway; Sunnaas Rehabilitation Hospital, Nesodden, Norway
,
Kristine Walhovd Centre for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway
,
Anders Fjell Centre for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway
,
Håkon Grydeland Centre for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway
&
Nils I. Landrø Centre for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway
Pages 139-151 | Received 13 Jul 2010, Accepted 30 Jan 2011, Published online: 25 Jul 2011
 
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Abstract

Cognitive impairment is a well-known consequence of acquired brain injuries, including stroke. Computerized cognitive training (CCT) is a rehabilitation approach intended to enhance cognitive functioning. It is unclear whether CCT leads to generalized cognitive improvements in daily life functioning, or if the subjects improve performance only on the exercises involved in the training. The current study explores whether fractional anisotropy (FA), a measure of white matter microstructure, may serve as an indirect biological indicator of enhanced neuropsychological functioning, particularly working memory, following CCT. The findings suggest a possible relationship between changes in FA measures and working memory.

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