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Abstract
Recent research revealed decreased access to semantic and associative networks in acute cocaine withdrawal. In autism, such behavioral outcomes are associated with decreased functional connectivity using functional magnetic resonance imaging. Therefore, we wished to determine whether connectivity is also decreased in acute cocaine withdrawal. Eight subjects in acute cocaine withdrawal were compared to controls for connectivity in language areas while performing a task involving categorization of words according to semantic and phonological relatedness. Acute withdrawal subjects had significantly less overall connectivity during semantic relatedness, and a trend towards less connectivity during phonological relatedness. Of potential future interest is whether this might serve as an imaging marker for treatment in patients.
Acknowledgments
This research was funded by a Biomedical Research Grant from the National Alliance for Autism Research (1033/DB//01/201/-005-00-00), by grants from NIDA (R21 DA015734) and NINDS (K23 NS43222), the OSU Research Investment Fund and the Wright Center for Innovation, and the University of Missouri Department of Radiology Research Investment Fund.