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Behavior, Cognition and Neuroscience
Volume 18, 2012 - Issue 5
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Original Articles

The functional magnetic resonance imaging-based verbal fluency test in obsessive–compulsive disorder

, , &
Pages 424-440 | Received 22 Oct 2010, Accepted 19 Jul 2011, Published online: 12 Dec 2011
 

Abstract

Clinical use of functional magnetic resonance imaging (fMRI) in obsessive–compulsive disorder (OCD) is limited by a relative absence of fMRI task development, standardization, and normative performance databases. We investigated the fMRI-based verbal fluency test (f-VFT) by quantitatively evaluating brain activation patterns in OCD participants (8 females and 4 males) compared with a normative database (16 females and 16 males). At the group level, OCD participants and references had highly similar activation in left-hemisphere language regions, including the precentral/premotor cortex, thalamus, basal ganglia, and inferior frontal gyrus/frontal operculum. At the interindividual level, however, the OCD group had highly variable activation patterns in the dorsal and ventral regions of the pre-supplementary motor area (pre-SMA) that may correspond with differences in demographic and clinical variables. Further, there were significant correlations in the OCD participants between pre-SMA dorsal and ventral activation and between dorsal pre-SMA activation and perfectionism. Our findings suggest considerable functional anatomical overlap in left-hemisphere language regions between OCD participants and references but significantly higher pre-SMA interindividual variability in OCD compared to the reference group that may be relevant in clinical fMRI application and the theoretical understanding of OCD.

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