Motor intentional disorders in vascular mild cognitive impairment and vascular dementia of subcortical type

Abstract

Subcortical vascular mild cognitive impairment (svMCI), a prodromal stage of subcortical vascular dementia (SVaD), is primarily associated with frontal injuries, whereas amnestic MCI (aMCI) is associated with temporoparietal injuries. Twenty-seven patients with svMCI, 20 with aMCI, 14 with SVaD, and 10 normal controls underwent motor intentional tasks (force initiation, development, maintenance, and termination) using a force dynamometer. Of the four motor intentional tasks, the maintenance task proved sensitive in differentiating svMCI from aMCI. In most motor intentional tasks, performances of svMCI patients were intermediate between those of controls and SVaD patients (initiation and termination: NC=aMCI=svMCI>SVaD; development: NC>aMCI=svMCI>SVaD; maintenance: NC=aMCI>svMCI=SVaD).

Keywords:

• Motor intentional disorder
• Subcortical vascular mild cognitive impairment
• Subcortical vascular dementia
• Motor akinesia
• Motor impersistence

This work was supported by a National Research Foundation of Korea (KRF) grant funded by the Korea government (MEST) (2010-0014026), by the Korea Science and Engineering Foundation (KOSEF) of the Korea government (MOST) (R01-2007-000-20754-0), by a grant of Korea Health Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A102065 & A090632), by a Samsung Medical Center Clinical Research Development Program grant (CRL-108011 & CRS 110-14-1), and by a Samsung Biomedical Research Institute grant (C-A7-209-3).