Advanced search
Publication Cover
Neurocase
Behavior, Cognition and Neuroscience
Volume 21, 2015 - Issue 5
Submit an article Journal homepage
484
Views
27
CrossRef citations to date
0
Altmetric
Original Articles

Finding my own way: an fMRI single case study of a subject with developmental topographical disorientation

Federico NemmiNeuropsychology Unit, Santa Lucia Foundation, Rome, Italy;Psychology Department, La Sapienza University, Rome, Italy;INSERM, U825, Université Paul-Sabatier, Toulouse, FranceCorrespondence[email protected]
View further author information
,
Filippo BianchiniNeuropsychology Unit, Santa Lucia Foundation, Rome, Italy;Psychology Department, La Sapienza University, Rome, ItalyView further author information
,
Federica PirasClinical and Behavioral Neurology Department, Neuropsychiatry Laboratory, Santa Lucia Foundation, Rome, ItalyView further author information
,
Patrice PéranINSERM, U825, Université Paul-Sabatier, Toulouse, FranceView further author information
,
Liana PalermoNeuropsychology Unit, Santa Lucia Foundation, Rome, Italy;Psychology Department, La Sapienza University, Rome, ItalyView further author information
,
Laura PiccardiNeuropsychology Unit, Santa Lucia Foundation, Rome, Italy;Life, Health and Environmental Science Department, L'Aquila University, L'Aquila, ItalyView further author information
,
Umberto SabatiniDepartment of Radiology, Santa Lucia Foundation, Rome, ItalyView further author information
&
Cecilia GuarigliaNeuropsychology Unit, Santa Lucia Foundation, Rome, Italy;Psychology Department, La Sapienza University, Rome, ItalyView further author information
 show all
Pages 573-583 | Received 27 Feb 2013, Accepted 27 Aug 2014, Published online: 03 Oct 2014
 
Sample our Behavioral Sciences journals, sign in here to start your access, latest two full volumes FREE to you for 14 days

Abstract

Developmental topographical disorientation (DTD) causes impaired spatial orientation and navigation from early childhood with no evidence of cerebral damage. Using fMRI and a landmark sequencing task, we investigated the hypothesis that Dr Wai’s abnormal cerebral activation pattern was related to his peculiar behavioral profile. Although Dr Wai was able to correctly perform landmark sequencing, he showed a lack of activity in regions activated in all control subjects and activity in areas that were not activated in any control subject. These results are discussed in light of cognitive and functional model of navigation, with relevant implications for DTD physiology.

Additional information

Funding

We received no specific grant from any commercial or non-profit funding agency to carry out this research.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 53.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 439.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.