Effect of the antiepileptic therapy on olfactory disorders associated with mesial temporal sclerosis

ABSTRACT

Parosmia has been described in neurological disorders, including temporal epilepsy. We reported a case of parosmia associated with unilateral hyposmia and mesial temporal sclerosis. We assessed the olfactory function by using Sniffin’ sticks test and olfactory event-related potentials (OERPs). The findings of unilateral deficit of identification associated with parosmia only in the side ipsilateral to mesial temporal sclerosis area, that involves temporal olfactory regions responsible for higher level of smell processing, suggest a central genesis of olfactory disorders. The administration of levetiracetam restored olfactory function, OERP N1-P2 amplitude, and mesial temporal sclerosis-related electroencephalographic findings.

KEYWORDS:

• Levetiracetam
• mesial sclerosis
• OERPs
• parosmia

Disclosure statement

No potential conflict of interest was reported by the authors.