Successful treatment of psychosis in a patient with Kufor-Rakeb syndrome with low dose aripiprazole: a case report

ABSTRACT

We present a case of a 32-year-old male with Kufor-Rakeb syndrome (KRS), a form of juvenile parkinsonism due to mutations of the ATP13A2 gene at PARK9 locus. The patient was seen for daily behavioral outbursts and psychotic symptoms. At first assessment, CGI scale was estimated at 5; “Markedly ill”. Aripiprazole was started at 2 mg and then increased to 3 mg. Two years later, psychotic symptoms were judged to be “much improved” (CGI-C = 2). This significant improvement without drug-induced motor side effects suggests that aripiprazole at low doses (2–5 mg) is effective and tolerated in patients with KRS.

KEYWORDS:

• Kufor-Rakeb syndrome
• juvenile parkinsonism
• neuronal ceroid lipofuscinosis
• psychosis
• Aripiprazole

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

No funding was received for this work