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Abstract
Objectives: The primary purpose of the study was to investigate a possible association between uterine fibroids and time to pregnancy (TTP), and, secondly, to explore the effect of myomectomy on TTP.
Methods: This historical cohort study used data from the Danish National Birth Cohort and the Danish National Patient Registry. The study population consisted of 86,323 women with 92,696 pregnancies. The main outcome was TTP; groups were compared using a binary outcome: TTP >12 months or TTP ≤12 months.
Results: Women who had a fibroid diagnosis code before attempting to conceive (n = 92) had an increased risk of TTP >12 months compared with women without a fibroid diagnosis code (n = 87,358) (adjusted odds ratio [OR] 1.67; 95% confidence interval [CI] 1.05, 6.68). Women who had a fibroid diagnosis code after pregnancy (n = 963) also had an increased risk of TTP >12 months compared with women without a fibroid diagnosis code (adjusted OR 1.24; 95% CI 1.04, 1.47).
Conclusion: We found an association between having a uterine fibroid diagnosis code and TTP >12 months. We were not able to make a valid assessment of the effect of myomectomy on TTP.
摘要
目的：该研究的主要目的是调查诊断有子宫肌瘤时到怀孕的时间（TTP）两者之间可能的联系。其次, 探讨子宫肌瘤切除术对TTP的影响。方法：这项历史性队列研究用的数据来自丹麦国家出生队列和丹麦国家病人登记处。研究人群包括86,323名女性共92,696次妊娠。主要结果是TTP。使用二分类结果比较各组：TTP > 12个月或TTP≤12个月。 结果：与没有诊断肌瘤的妇女（n=87,358）相比, 尝试受孕前诊断有肌瘤的妇女（n=92）, TTP> 12个月风险增加（调整后的比值比[OR] 1.67； 95％置信区间[CI] 1.05, 6.68）。与没有诊断肌瘤的妇女相比, 妊娠后有肌瘤诊断的妇女（n=963）TTP> 12个月（校正后OR为1.24； 95％CI 1.04, 1.47）风险也会增加。 结论：我们发现具有子宫肌瘤诊断与TTP> 12个月之间存在关联。 但我们无法有效评估子宫肌瘤切除术对TTP的影响。
Acknowledgements
The authors thank P. Kristensen for her help in editing the manuscript.
Disclosure statement
No potential conflict of interest was reported by the author(s).