Combination of mifepristone and misoprostol vs misoprostol monotherapy for treatment of second-trimester pregnancy loss

Abstract

Objective

Our main goal was to evaluate whether a treatment protocol based on the combination of mifepristone and misoprostol for second-trimester foetal loss was more effective than misoprostol monotherapy.

Methods

This was an observational, retrospective, cross-sectional two-centre study of women receiving treatment for second-trimester pregnancy loss. Patients were recruited in two centres that used different treatment protocols: combined mifepristone–misoprostol treatment or misoprostol monotherapy.

Results

A total of 99 patients were included in the study: 41 in the mifepristone–misoprostol combined treatment group and 58 in the misoprostol monotherapy group. The combined treatment group had shorter times to expulsion and shorter hospitalisations, as well as higher rates of hospital discharge within 24 h and complete abortion within the first 6 h and 12 h. There were no differences regarding secondary effects and complication rates.

Conclusion

A combination of mifepristone and misoprostol appears to be a feasible option for the treatment of second-trimester pregnancy loss.

摘要

目的：我们的主要目标是评估基于米非司酮和米索前列醇联合治疗妊娠中期胎儿流产的治疗方案是否比单用米索前列醇治疗更有效。

方法：这是一项观察性、回顾性、横断面双中心研究, 对象为因妊娠中期流产而接受治疗的女性。在两个使用不同治疗方案的中心招募患者：米非司酮-米索前列醇联合治疗或单用米索前列醇治疗。

结果：共有 99 例患者被纳入研究：米非司酮-米索前列醇联合治疗组 41 例, 米索前列醇单药治疗组 58 例。联合治疗组的出院时间更短, 住院时间更短, 24 小时内出院率更高, 6小时和 12 小时内完全流产率更高。次要影响和并发症发生率没有差异。

结论：米非司酮和米索前列醇的联用治疗似乎是治疗妊娠中期流产的可行选择。

Keywords:

• Effectiveness
• foetal demise
• mifepristone
• misoprostol
• second-trimester pregnancy loss

Disclosure statement

No potential conflict of interest was reported by the authors.