Real-world satisfaction and menstrual bleeding pattern with available LNG-IUD among Spanish young women

Abstract

Objective

The aim of this study was to evaluate the satisfaction and menstrual bleeding pattern with levonorgestrel-releasing intrauterine systems (LNG-IUD) in young women.

Methods

A prospective, multicentre, non-interventional study with 1-year follow-up was conducted in Spain. Participants were women between 18 and 30 years old who freely choose any available LNG-IUD for contraception. Satisfaction with LNG-IUD was measured with a 5-point Likert scale. Type of LNG-IUD, menstrual bleeding pattern and satisfaction with it, easiness of insertion and pain during procedure were collected.

Results

A total of 555 women (37.3% parous, 62.7% nulliparous) (mean age 25.8 ± 3.5) completed the study. After 12 months, 92.4% of women were satisfied or very satisfied with the LNG-IUD, with no differences by parity status, type of IUD or baseline menstrual bleeding pattern. Satisfaction with the LNG-IUD correlated with satisfaction with menstrual bleeding pattern at 12 months. Up to 88.7% of women were satisfied or very satisfied with their menstrual bleeding pattern at 12 months in comparison to 41.5% at baseline (p < 0.001). Adverse events (AE)-related discontinuation rate was low (2.2%).

Conclusions

Satisfaction with LNG-IUD is very high among young Spanish women, regardless of parity and menstrual bleeding pattern at baseline.

摘要

目的：本研究的目的是评价年轻女性应用左炔诺孕酮宫内节育器（LNG-IUD）的满意度和月经出血模式。

方法：在西班牙进行了一项前瞻性、多中心、非干预性研究, 随访时间为1年。参与者是年龄在18岁到30岁之间的女性, 她们自由选择任何可用的LNG-IUD用于避孕。对LNG-IUD的满意度采用5分Likert评分。记录放置LNG-IUD的类型、月经出血模式及满意度、放置难易程度及术中疼痛情况。

结果：共有555名女性（37.3%的产妇, 62.7%的未产妇）（平均年龄25.8±3.5岁）完成了本研究。12个月后, 92.4%的女性对LNG-IUD感到满意或非常满意, 不同产次、IUD类型和基线月经出血模式没有差异。12个月时对LNG-IUD的满意度与对月经出血模式的满意度相关。高达88.7%的女性在12个月时对自己的月经出血模式感到满意或非常满意, 而基线时这一比例为41.5%（p<0.001）。不良事件（AE）相关的停药率较低（2.2%）。

结论：西班牙年轻女性对LNG-IUD的满意度非常高, 无论基线时的产次和月经出血模式如何。

Keywords:

• Intrauterine system
• levonorgestrel-releasing intrauterine device
• contraceptive satisfaction
• menstrual bleeding pattern
• parity status

Acknowledgments

The sponsorship consisted in providing the services from an independent company, Adelphi Targis who contributed to the bibliographical review, debriefing process and editorial support. Data interpretation and preparation of the manuscript were the responsibility of the study investigators. Medical writing support was provided by Alba Gomez, PhD and Alba Llopis, PhD. The authors thank all the investigators for their participation and continued commitment to the study.

Disclosure statement

Perelló J has received honoraria for clinical training and consulting activities in relation with contraception from Bayer Hispania S.L. MSD, Theramex, Exeltis y Gynea-Kern. Lopez G declares no conflicts of interest. Rius-Tarruella, J is employed fulltime for Bayer Hispania S.L. Calaf J has received honoraria for clinical training and consulting activities in relation with contraception from Bayer Hispania S.L. and Gedeon Richter – Preglem S.A.

Additional information

Funding

This study was sponsored by Bayer Hispania S.L.