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Original

Physical function and fitness in long-term survivors of childhood leukaemia

, , Msc, PhD, , , , & show all
Pages 267-274 | Received 06 May 2005, Accepted 14 Oct 2005, Published online: 10 Jul 2009
 

Abstract

Objective: To evaluate the physical function and fitness in survivors of childhood leukaemia 5–6 years after cessation of chemotherapy.

Materials and methods: Thirteen children (six boys and seven girls; mean age 15.5 years) who were treated for leukaemia were studied 5–6 years after cessation of therapy. Physical function and fitness were determined by anthropometry, motor performance, muscle strength, anaerobic and aerobic exercise capacity.

Results: On motor performance, seven of the 13 patients showed significant problems in the hand-eye co-ordination domain. Muscle strength only showed a significantly lower value in the mean strength of the knee extensors. The aerobic and the anaerobic capacity were both significantly reduced compared to reference values.

Conclusion: Even 5–6 years after cessation of childhood leukaemia treatment, there are still clear late effects on motor performance and physical fitness. Chemotherapy-induced neuropathy and muscle atrophies are probably the prominent cause for these reduced test results. Physical training might be indicated for patients surviving leukaemia to improve fitness levels and muscle strength.

Objetivo: Evaluar la capacidad y la función física de sobrevivientes de leucemia, 5 a 6 años después de suspender la quimioterapia.

Material y métodos: trece niños (6 niños y 7 niñas, con edades promedio de 15.5 años) que fueron tratados por leucemia fueron estudiados 5 a 6 años después de suspender la terapia. La capacidad y la función física fueron determinadas por medio de la antropometría, la actividad motora, la fuerza muscular, la capacidad de realizar ejercicio aeróbico y anaeróbico.

Resultados: En la actividad motora 7 de los 13 pacientes mostraron problemas significativos en la coordinación ojo-mano. La potencia muscular mostró solamente un valor significativamente bajo en el promedio de la fuerza de los extensores de la rodilla. Tanto la capacidad aeróbica como la anaeróbica estuvieron reducidas en comparación a los valores de referencia.

Conclusión: 5 a 6 años después de haber suspendido el tratamiento de la leucemia en la infancia, aún hay efectos tardíos claros que repercuten en la actividad motora y la capacidad física. La neuropatía inducida por la quimioterpia y las atrofias musculares, son probablemente las causas mas prominentes de la disminución de los resultados en estas pruebas.

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