Processing Speed: A Strong Predictor of Verbal Memory Performance in Schizophrenia

The role of slowing of processing speed in verbal memory impairment in patients with schizophrenia was investigated. Forty-one patients with schizophrenia and 41 healthy control subjects were administered a verbal memory task involving free recall of three lists of words, which varied in their degree of semantic organization. Standard processing speed tests were administered as well. Regression analyses were conducted on the number of words recalled in each list. A global processing speed measure was a significant predictor of the recall of each list in patients. Patients were very significantly impaired in the recall of the three lists relative to healthy controls. However, when the processing speed measure was entered in the regression, the significance of diagnosis was considerably reduced for one of the lists, with no semantic organization, and eliminated for the other two lists which contained semantic organization. These findings suggest that slowing in processing speed is an important contributor to verbal memory impairment in patients with schizophrenia. The possible role of various specific slowing functions is discussed.

The first author was funded by grants from the Leverhulme Trust and from the Bial Foundation, and by the Alexander Gralnick Grant for Research on Schizophrenia, American Psychological Foundation. We gratefully acknowledge awards from Baily Thomas Charitable Trust, Barnwood House Trust, Making Space, PF Charitable Trust, Sir Samuel Scott of Yews Trust, and Welton Foundation.

Notes

The first author was funded by grants from the Leverhulme Trust and from the Bial Foundation, and by the Alexander Gralnick Grant for Research on Schizophrenia, American Psychological Foundation. We gratefully acknowledge awards from Baily Thomas Charitable Trust, Barnwood House Trust, Making Space, PF Charitable Trust, Sir Samuel Scott of Yews Trust, and Welton Foundation.