Mild cognitive impairment subcategories depend on the source of norms

Abstract

The diagnosis of mild cognitive impairment (MCI) entails evidence of objective cognitive loss using neuropsychological measures. In this study, we examined whether the presence and degree of objective cognitive impairment varied according to the use of published versus local norms. We also varied the cutoff scores at which impairment was recognized and examined whether this altered inclusion in MCI subcategories. We found that the use of different comparison normative groups altered the subcategory diagnoses, especially when the cutoff score for impairment was conservative. In general, local norms were more stringent than published norms. We discuss the implications of these results for MCI diagnosis and categorization.

Keywords:

• Mild cognitive impairment
• Subcategories
• Normative data
• Normal aging
• Neuropsychological tests

Notes

This study was supported in part by operating grants from the Canadian Institutes of Health Research (CIHR) and the Fonds de la Recherche en Santé du Québec (FRSQ) awarded to H.C.