Abstract
Chronic low-level occupational exposure to manganese (Mn) is reportedly associated with the development of Parkinsonian-like symptoms. In a study of 143 manganese smelter workers, inhalable Mn exposure was associated with lower performances on the Digit Symbol Coding and Stroop tests; respirable Mn exposure was associated with improved Digit Symbol Coding test performance and reduced performance on the Trail Making (Part A), Matrix Reasoning, and Stroop tests. While these relationships reached statistical significance, the magnitude of these effects was significantly smaller than the standard error of measurement of the neuropsychological tests, indicating that these differences are not of clinical significance.
Acknowledgments
This research was funded by an Australian Research Council Linkage Project Grant (LPO455174). The authors would like to express their gratitude to Alastair Warren and Paula Northam, who were of great assistance in the conduct of this project, as well as to the management and staff of the Tasmanian Electrometallurgical Company (TEMCO) for supporting this project.