Processing speed and working memory training in multiple sclerosis: A double-blind randomized controlled pilot study

Abstract

Between 40–65% of multiple sclerosis patients experience cognitive deficits, with processing speed and working memory most commonly affected. This pilot study investigated the effect of computerized cognitive training focused on improving processing speed and working memory. Participants were randomized into either an active or a sham training group and engaged in six weeks of training. The active training group improved on a measure of processing speed and attention following cognitive training, and data trended toward significance on measures of other domains. Results provide preliminary evidence that cognitive training with multiple sclerosis patients may produce moderate improvement in select areas of cognitive functioning.

Keywords:

• Multiple sclerosis
• Cognitive training
• Processing speed
• Working memory
• Computer-based training

The authors would like to express their gratitude to hard-working research assistants Joanie Thelen, Lowell Fletcher, Justin McGee, and Brandon Roberg. The authors would also like to thank Brent Baker for software development and technical support.

Additional information

Funding

This study was funded by University of Kansas Endowment: Boelte Family Fund for Multiple Sclerosis.